L.A. Lepilina, O.V. Minayaeva, L.R. Gabitova, T.P. Tirnova, Yu.Yu. Smolkiva
Bashkir Medical State University, Ufa, Rusaia
The influence of hormone level on the course of systemic sclerodermy (SSD) hasn’t been studied sufficiently. It is known that this disease is 11 times as frequent in female patients than in male. Severe unfavourable course is marked in puberty or climax age. The development of pathologic process is often due to parturition or abortions. The condition of hypothalamus and hypophysial adrenal systems in SSD patients is studied in detail. There are findings of hormone changes contents especially estradiol and gonadotropins on disease course (Lepilina L.A., 1993). We haven’t met the findings about the condition of hypothalamus and hypophyso-thyroid glands systems.
The aim of our investigation is to study thyroid findings (T3, T4, TTG) in SSD patients and to estimate the efficiency of complex treatment according to its dynamics. Throughout SSD complex therapy we have used nonsteroid inflammatory drugs, glycocorticoids 5-15 mg doses and laser treatment. According to the mathodics the patients were divided into 2 groups: the first group received laser therapy with the use of general, local and segmental acupuncture. HeNe laser «Alpha2» was used for treatment with power stream 1-2 mVt/sm2 at the outlet. The second group included patients with intravenous laserothorapy with “Aloo-1” apparatus, 5 sittings for an hour. The estimation of results demonstrated the reduction of the 1st group intensity (P 0,05) and frequency of Reino (P 0,05) syndrome attacks. The decreased T3 (P 0,05) level was not changed, TTG content reduced (P 0,05). In the second group we observed the reduction of frequency and Rein syndrome (P 0,05, P 0,5). Along side with positive dynamics of clinical findings statistically meaningful of T3 and TTG (P 0,05, p 0,05) content change was marked.